OZONE IN NON-RHEUMATIC LOCOMOTOR SYSTEM PATHOLOGIES
Alexandre, J. Baeza Noci, V. Sheel Kumar
Биорадикалы и Антиоксиданты. Том 2, №1, Стр. 6-20
Ключевые слова: озон, озонотерапия, заболевания позвоночника, тендопатии, остеоартрит, туннельные синдромы
Статья опубликована с разрешения Международного научного комитета по проблемам озонотерапии (The Scientific International Committee of Ozone Therapy – ISCO3, www.aepromo.org/en/isco3.php.)
В обзоре, включающем анализ достижений озонотерапии за последние два десятилетия, рассмотрено современнее состояние и применимость метода в ревматологии, неврологии, нейрохирургии и ортопедии. Рассмотрены возможности использования медицинского озона при тендопатиях, остеоартритах и т. д. Отдельное внимание уделено озонотерапии неврологической патологии (в частности, туннельным синдромам), заболеваний позвоночника. Обсуждаются способы введения озона и оптимальные его дозы. Кратко рассмотрены противопоказания к озонотерапии для контингента пациентов с неревматичекой патологией опорно-двигательного аппарата.
Ключевые слова: озон, озонотерапия, заболевания позвоночника, тендопатии, остеоартрит, туннельные синдромы
- Verga C. Nuovo approccio terapeutico alle ernie e protusioni discali lombari // Rivista Di Neuroradiologia. 1989. Vol. 2. P. 148.
- Riva Sanseverino E. Knee joint disorders treated by oxigen-ozone therapy // Europa Medicophysica. 1989. Vol. 25. N3. P. 163-170.
- Escarpenter J., Valdes O. Resultados terapéuticos en la osteoartritis de la rodilla con infiltraciones de ozono // Revista Cubana de Investigación Biomédica. 1997. Vol. 16. P. 124–132.
- Gheza G., Ipprio L., Bissolotti L. Oxygen-Ozone Therapy in a Diabetic Patient with De Quervain’s Tenosynovitis Associated with Joint Arthrosis // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 2. N1. P. 189-192.
- Gaffuri M, Garaffo R, Gheza G. Oxygen-Ozone Therapy for Lateral Humeral Epicondylitis: Preliminary Findings // Riv. Ital. Ossigeno-Ozonoterapia. 2003. Vol. 2. N2. P. 169-172.
- Gheza G., Bissolotti L. Intra-articular Oxygen-Ozone Injection for Knee Биорадикалы и Антиоксиданты 2015 Том 2, No1 15 Disease Proposed Guidelines // Riv. Ital. Ossigeno-Ozonoterapia. 2003. Vol. 2. N1. P. 63–66.
- Moretti B., Lanzisera R., Morese A. et al. O2-O3 vs Chondroprotectors in the Treatment of Osteoarthritis of the Knee // Riv Ital Ossigeno-Ozonoterapia. 2004 Vol. 3. N1. P. 65–72.
- Pribluda S. Treatment of Lumbosciatica and Other Similar Syndromes with Subcutaneous Ozone // Sem. Med. 1963. Vol. 123. P. 1026–1028.
- Magalhaes E., Dotta L., Sasse A. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials // Pain Physician. Vol. 15, N2. P. E115–129.
- Ceccherelli F., Gagliardi G., Faggian L. et al. Analgesic effect of subcutaneous administration of oxygen-ozone. A blind study in the rat on the modulation of the capsaicin-induced edema // Acupunct. Electrother. Res. 1998. Vol. 23. N3-4. P. 171-184.
- Iliakis E.M., Valadakis V., Vynios D. et al. Rationalization of the activity of medical ozone on intervertebral disc: a histological and biochemical study // Rivista di Neuroradiologia. 2001, N14. Suppl. 1. P. 23-30.
- Iliakis E., Petropoulos I., Iliaki A. et al. Is Medical Ozone Safe when Injected Intra-articularly? // International Journal of Ozone Therapy. 2008. N7.
- Bin Yu. Ozone treatment in osteoarthritis; basic and clinical investigation // Proc. of the IV Meeting of the CFOT (Internet). Shenyang; 2012. http://www.cfot.org.cn/news_view.asp?id=364
- Kim Y., Jeon B., Kwon K. Ozone Chemonucleolysis on the Lumbar Intervertebral Disc of the Rabbit // J. Korean Neurosurg. Soc. 2003. Vol. 34. N6. P. 570-574.
- Li S., Yu G., Chen G. Impact of different concentrations of ozone injection on pathological changes of rabbit skeletal muscle // J. Modern Clin. Med. Bioeng. (Internet). 2006. N6. http://en.cnki.com.cn/Article_en/CJFDTOTAL-
XDLC200606012.htm - Castrini A., Prignacca E. Treatment Protocol for Herniated Disc with Oxygen-Ozone Therapy in Dog // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 1, N1. P. 113-115.
- Yu Z., He X., Chen Y. Influence of ozone on the ultrastructures of nucleus pulposus // J. Intervent. Radiol. (Internet). 2001. N3. http://en.cnki.com.cn/Article_en/CJFDTOTAL-JRFS200103017.htm
- Yu Z., He X., Chen Y. et al. // Chin. J. Radiol. [Internet]. 2002. Vol. 50. N4. http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHGS200204023.htm
- Algara C., Garcia O. Oxygen-ozone percutaneous nucleolysis: an animal model study // Proc. of the 1st world congress on minimally spine surgery. Honolulu; 2008.
- Muto M. Intradiscal and Intramuscolar Injection of Oxygen-Ozone: Pathological Evaluation. Work in Progress // Riv. Ital. Ossigeno-Ozonoterapia. 2004. Vol. 3. N1. P. 7-13.
- Tian J., Zhang J-Sh., Xiao Y. et al. Oxidative effect of different concentration of ozone injected into porcine normal lumbar disks // Chin. J. Intervent. Биорадикалы и Антиоксиданты 2015 Том 2, No1 16 Imaging Ther. (Internet). 2007. N4. http://en.cnki.com.cn/Article_en/CJFDTOTAL-
JRYX200704018.htm - Alexandre A., Buric J., Paradiso R. et al. Intradiscal injection of O2-O3 to treat lumbar disc herniations // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 1. N2. P. 165-169.
- Andreula C., Muto M., Leonardi M. Interventional spinal procedures // Eur. J. Radiol. 2004. Vol. 50. N2. P. 112-119.
- Alexandre A., Corò L., Azuelos A. et al. Intradiscal injection of oxygen-ozone gas mixture for the treatment of cervical disc herniations // Acta Neurochir. 2005. Vol. 92. Suppl. P. 79-82.
- Tian J.L., Zhang J.S., Xiao Y.Y. et al. Changes of CSF and spinal pathomorphology after high-concentration ozone injection into the subarachnoid space: an experimental study in pigs // AJNR Am. J. Neuroradiol. 2007. Vol. 28. N6. P. 1051-1054.
- Yu B., Lin Q.-R., Wang B.-W. et al. Effect of Intra-Articular Ozone Injection on Degenerative Knee Cartilage in Rats // Int. J. Ozone Ther. 2010. Vol. 9. N1. P. 14–20.
- Paoloni M., Di Sante L., Cacchio A. et al. Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter,randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection // Spine. 2009.Vol. 34, N13. P. 1337-1344.
- Steppan J., Meaders T., Muto M., Murphy K. A metaanalysis of the effectiveness and safety of ozone treatments for herniated lumbar discs // J. Vasc. Interv. Radiol. 2010. Vol. 21. N4. P. 534-548.
- Bocci V. General mechanisms of action of ozonetherapy and pain related mechanism // Rev. Esp. Soc. Dolor. 2005. Vol. 12. N II. P. 24-36.
- Bocci V. Ozone: A new medical drug (Internet). Netherlands: Springer, 2005. 295 p.
- López-Laserna Ruiz J. Results of Conservative Treatment of Tarsal Tunnel Syndrome: Medical Ozone Infiltration and Surgery // Revista Española de Ozonoterapia. 2012. P. 62.
- García-González B., García-Muñoz W., Játiva-Silvestre F. Infiltraciones locales en Cirugía Ortopëdica y Traumatología. Manual de Cirugía Ortopédica y Traumatología - SECOT. 2a ed. Madrid: Editorial Médica Panamericana; 2010. P. 334-342.
- Gjonovich A., Girotto L., Sattin G. et al. Oxygen-Ozone Therapy in Shoulder Pain: Clinical Experience // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 1. N1. P. 37-40.
- Moretti B., Lanzisera R., Sisti G.L. et al. O2-O3 therapy in tendinopathies and entrapment syndromes // Riv. Ital. Ossigeno-Ozonoterapia. 2005. Vol. 4. N1. P. 20-29.
- De Lucas J. Ozone peripherical infiltration. Indications, techniques and clinical experience // Rev. Esp. Soc. Dolor. 2005. Vol. Vol. 12. N II. P. 37-47.
- Moretti M. Can Oxygen–Ozone Injections in Sport Overuse Tendinopathies Be a Valid Alternative to Cortisone Therapy? // Int J Ozone Ther. 2010. Vol. 9. N1. P. 21-24.
- Moretti M. Effectiveness of Oxygen-Ozone and Hyaluronic Acid Injections in De Quervain’s Syndrome // Int. J. Ozone Ther. 2012. Vol. 11. N1. P. 31-33.
- Trenti G., Gheza G. Efficacy of Oxygen-Ozone Pain Therapy Associated with Shock Waves to Treat Calcifying Tendinitis of the Shoulder // Riv. Ital. Ossigeno-
Ozonoterapia. 2002. Vol. 1. N1. P. 45-50. - Benvenuti P. Oxygen-Ozone Treatment of the Knee, Shoulder and Hip // Riv. Ital. Ossigeno-Ozonoterapia. 2006. Vol. 5. N2. P. 135-144.
- Ikonomidis S., Caralambus D., Vakirtzian L., Iliakis E. Nonoperative Treatment of Shoulder Impingement Syndrome with Topical Injections of Medical Oxygen-Ozone Mixture. A double blind clinical trial // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 1, N1. P. 41-44.
- Bonetti M. Oxygen-ozone therapy vs epidural steroids injections - CT evaluation // Rivista Di Neuroradiologia. 2000. Vol. 13. N2. P. 203-206.
- Baeza-Noci J. Ozonoterapia intrarticular en la gonartrosis // II Curso Teorico ACEOOT. Jeréz de la Frontera; 2006.
- Huanqi C., Cruz M. Eficacia y seguridad del ozono intraarticular en artrosis de rodilla refractaria al tratamiento // Rev. Per. Reum. 2006. Vol. 12. N1. P. 21-26.
- Baeza-Noci J. Guideline for ozone therapy in degenerative joint diseases // II Meeting of the CFOT. Urumqi; 2008.
- Rogelio Milanes J., Acosta Rivera W., Trinchet Ayala E., Hernández Rosales F. The ozonotherapy/Results of the treatment in patients with symptomatic degenerative arthrosis of the knee // Dolor, Clinica y Terapia. 2009. Vol. 6. N4. P. 18-24.
- Baeza-Noci J. Osteoartrosis de rodilla. Resultados de la ozonoterapia // II Congreso Nacional SEOT. Marbella; 2009.
- Guo D, Zhang X. Study on treatment for knee osteoarthritis by medical ozone // Gansu Med. J. 2010. N1. P. 10-11.
- Moretti M. Effectiveness of Treatment with Oxygen-Ozone and Hyaluronic Acid in Osteoarthritis of the Knee // Int. J. Ozone Ther. 2010. Vol. 9. N1. P. 25-29.
- Wang J., Zhang Y., Ma Y. Therapeutic Effect of Low Concentration Medical Ozone on Knee Osteoarthritis // J. Liaoning Coll. Tradit. Chin Med. 2010. Vol. 12. N4. P. 17-19.
- Baeza-Noci J. Knee osteoarthritis: ozone therapy results // IV International Ozone Congress. Dehli, 2010.
- Mishra S.K., Pramanik R., Das P. et al. Role of intra-articulra ozone in osteo-arthritis of knee for functional and symptomatic improvement // Ind. J. Phys. Med. Rehabilit. 2011. Vol. 22. N2. P. 65-69.
- Aymale CA. Ozonoterapia en patología artrósica quirúrgica de rodilla Ozone therapy in surgical pathology of arthritic knee // Rio de Janeiro (Brazil). 2011.
- Baeza-Noci J. Ozonoterapia en la gonartrosis y la coxartrosis Ozonetherapy in osteoarthritis // Rio de Janeiro (Brazil), 2011.
- Baeza-Noci J. Ozonoterapia en la gonartrosis y la coxartrosis // XXXIV Congreso de la SIBB. Córdoba, 2011.
- Baeza-Noci J. Ozonoterapia en la patología de cadera del adulto // IX Congreso de la ACEOOT. Granada, 2011.
- Baeza-Noci J. Ozone therapy in adult hip pathology // III Meeting of the WFOOT. Brescia, Italy; 2011.
- Cabot Dalmau J. Combined Technique of Ozontherapy and Platelet Derived Growth Factors in the Knee Osteoarthritis (Técnica Combinada de Ozonoterapia y Factores de Crecimiento en la Artrosis de Rodilla) // Revista Española de Ozonoterapia; 2011. P. 34-35.
- Baeza-Noci J. Ozone and rich-platelet plasma: a good team for knee osteoarthritis. IV Meeting of the CFOT. Shenyang; 2012.
- Zambello A., Fumagalli L., Fara B., Bianchi M. Oxygen-Ozone Treatment of Carpal Tunnel Syndrome. Retrospective Study and Literature Review of Conservative and Surgical Techniques // International Journal of Ozone Therapy. 2008. Vol. 7. N1. P. 45-48.
- Bocci V. Is it true that ozone is always toxic? The end of a dogma // Toxicol. Appl Pharmacol. 2006. Vol. 216. N3. P. 493–504.
- Baeza-Noci J. Ozone spinal infiltration. Physiopathology and mechanism of action Rev Esp Soc Dolor. 2005. Vol. 12[II]. P. 18-23.
- Scuccimarra A. The ―Laminoforaminal Technique‖ in Oxygen-Ozone Therapy for Lumbar Disc Herniation // Riv. Ital. Ossigeno-Ozonoterapia. 2003. Vol. 2. N2. P. 193-196.
- Zambello A., Fara B., Bianchi M., Tabaracci G. Paravertebral Oxygen-
Ozone Infiltrations: High versus Low Doses: towards the Minimum Effective Dose // Int. J. Ozone Ther. 2007. Vol. 6. N1. P. 37-41. - Verga C. Il perché ed il come dell’ossigeno ozono nel trattamento della patologia ortopedica // Ossigeno Ozono Terapia: Pratica medica tra certezze e prospettive terapeutiche. Sorrento; 2004.
- Muto M., Andreula C., Leonardi M. Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone [O2-O3] injection // J. Neuroradiol. 2004. Vol. 31. N3. P. 183-189.
- Juncopilla N., Franzini M. The therapy involving the infiltration of oxygen-
ozone intradisc and interfacet // 1er Congresso de la Sociedad Española de abordajes percutaneos vertebrales. Barcelona; 1995. - Dall’aglio R., Gomez Moraleda M., Cardoso C. et al. Biochemical and Pharmaceutical Aspects of Entrapment: the Possible Role of Free Radicals and Ozone in Nerve Root Compression// Riv. Ital. Ossigeno-Ozonoterapia. 2004. Vol. 3, N2. P. 105-111.
- Murga M. Ozone spinal infiltration. Indications, techniques and clinical experience // Rev. Esp. Soc. Dolor. 2005. Vol. 12. N II. P. 10-17.
- Leonardi M. Disc Puncture under Fluoroscopic Guidance // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 1. N 1. P. 73-78.
- Andreula C.F., Simonetti L., De Santis F. et al. Minimally invasive oxygen-
ozone therapy for lumbar disk herniation // AJNR Am. J. Neuroradiol. 2003. Vol. 24. N5. P. 996–1000. - He X., Yu Z., Teng G. et al. Treatment of lumbar disc herniation by using percutaneous intradiscal and paraspinal space injection of O_2-O_3 mixture // Chin. J. Radiol. (Internet). 2003. N9. Retrieved from: http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHGS200309018.htm
- Buric J., Molino Lova R. Ozone chemonucleolysis in non-contained lumbar disc herniations: a pilot study with 12 months follow-up // Acta Neurochir. Suppl. 2005. Vol. 92. P. 93-97.
- He X.F., Yu Z.J., Li Y.H. et al. Percutaneous injection of intradiscal and paraspinal space with O2-O3 mixture to treat lumbar disc herniation // Riv. Ital. Ossigeno-Ozonoterapia. 2003. Vol. 2. N2. P. 135-138.
- He X., Li Y., Chen H. et al. Intradiscal injection of O_2-O_3 to treat lumbar disc herniations: clinical therapeutic effect analysis with 600 cases // Chin. J. Intervent. Imaging Ther. (Internet). 2005. Vol. 2. N5. http://en.cnki.com.cn/Article_en/CJFDTotal-
JRYX200505004.htm - Buric J., Alexandre A., Corò L., Azuelos A. Intradiscal Ozone Treatment of Non-Contained Disc Herniations. 18 Months Follow-up // Riv. Ital. Ossigeno-
Ozonoterapia. 2003. Vol. 2. N2. P. 153-160. - Wang J., Li H., Wang G. Studies on the concentration of oxygen-ozone in percutaneous intradiscal oxygen-ozone-injection for the treatment of lumber disc herniation // Chin. J. Spine Spinal Cord (Internet). 2007. N11. http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZJZS200711010.htm
- Paradiso R., Alexandre A. The different outcomes of patients with disc herniation treated either by microdiscectomy, or by intradiscal ozone injection // Acta Neurochir Suppl. 2005. Vol. 92. P. 139-142.
- Bonetti M. CT-Guided Intraforaminal Technique // Riv. Ital. Ossigeno-
Ozonoterapia. 2002. Vol. 1. N1. P. 69-71. - Andreula C. Lumbosacral Herniated Discs: Chemodiscolysis with Nucleophthesis with O2-O3 and Periradicular and Periganglionic Infiltration under CT Guidance Personal Experience // Riv. Ital. Ossigeno-Ozonoterapia. 2002. Vol. 1. N1. P. 79-85.
- Andreula C. Ozone therapy // Neuroradiology. 2011. Vol. 53. Suppl. 1. P. S207-209.
- Mattozi I., Laurini G., Muzzi G. et al. Intrasacral epidural injection with oxygen-ozone for the treatment of low back pain. Comparison and evaluation with other techniques and rehabilitation and return to work // European Journal of Clinical Investigation. 2003. Vol. 33 [suppl. 1]. P. 45.
- Morales E. Peridural ozone therapy in disc-radicular conflcit and lumbosciatalgia // Jornadas Científicas SEOT 2012. Valencia; 2012.
- Baeza-Noci J. Spinal ozone therapy - state of the art // Congreso Nazionale FIO. Bologna; 2007.
- Baeza-Noci J. Rational use of ozone therapy in degenerative spinal pathologies// 6th European Course ―Minimally invasive surgery of the spine.‖ Treviso; 2008.
- Baeza-Noci J., Kumar V. Ozone discectomy (ozonucleolysis) for discogenic radiculopathy arising from disc herniation: one year follow-up study from Indian and Spanish centres. Spineweek. Geneve; 2008.
- Baeza-Noci J. Ozone Therapy in the Musculo-Skeletal Pathology: Spine // III Meeting of the WFOOT. Brescia, Italy; 2011.
- Bonetti M. CT-Guided Oxygen-Ozone Infiltration into Isthmic Lysis Points in the Management of 1st Degree Spondylolisthesis and Spondylolysis // Riv. Ital.Ossigeno-Ozonoterapia. 2003. Vol. 2. N1. P. 31-38.
- Bonetti M., Fontana A., Albertini F. CT-guided oxygen-ozone treatment for first degree spondylolisthesis and spondylolysis // Acta Neurochir. Suppl. 2005. Vol. 92. P. 87-92.
- Bonetti M., Cotticelli B., Richelmi P., Valdenassi L. Rofecoxib and O2-O3 Therapy vs O2-O3 Therapy in the Management of Spondylarthrosis // Riv. Ital.Ossigeno-Ozonoterapia. 2002. Vol. 1. N2. P. 171-178.
- Bonetti M., Fontana A., Mardighian D. Oxygen-ozone therapy for degenerative spine disease in the elderly // Riv. Ital. Ossigeno-Ozonoterapia. 2006. Vol. 5. N1. P. 25-32.
- Bonetti M., Fontana A., Parodi F. Oxygen-Ozone Therapy Associated with Magnetic Bioresonance in Degenerative Arthrosis of the Spine: Preliminary Findings // Int. J. Ozone Ther. 2007. Vol. 6. N1. P. 29-35.
- Bonetti M., Fontana A., Martinelli F., Andreula C. Oxygen-ozone therapy for degenerative spine disease in the elderly: a prospective study // Acta Neurochir. Suppl. 2011. Vol. 108. P. 137-142.
- Baeza-Noci J. Spinal Ozone Therapy in Lumbar Spinal Stenosis // Int. J. Ozone Ther. 2007. Vol. 6. N1. P. 17-24.